Synthesis of 5-fluorouracil from orotic acid.
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چکیده
منابع مشابه
The Synthesis of Orotic Acid-C14O2H
Orotic acid-C1402H, which was required for biological studies being pursued in this laboratory, has been synthesized by the method of Nyc and Mitchell,5 starting with DL-aspartic acid-a-C1402H. The latter was prepared from ethyl malonate-C1402C2H5, as described by Galat.' This orotic acid probably contains the isotopic carbon exclusively in the carboxyl group since it evolves carbon dioxide con...
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An improved method for the synthesis of N1-substituted orotic acid derivatives is reported. The method involves sequential incorporation of nitrogen atoms to the pyrimidine structure from simple starting materials and thus allows the synthesis of N1-substituted orotic acid derivatives with single 15N label at either N-1 or N-3.
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ژورنال
عنوان ژورنال: NIPPON KAGAKU KAISHI
سال: 1985
ISSN: 2185-0925,0369-4577
DOI: 10.1246/nikkashi.1985.2185